The present study investigated the effect of doxycycline (100mg/5ml) on human platelet function. The study was conducted on human platelets from healthy volunteers, as well as from patients with and without previous platelet injury, and a subcutaneous platelet injury (PlpI) was induced in a rabbit. A single dose of doxycycline (100mg/5ml) was administered to the platelets, and the platelet function was evaluated by measuring the platelet aggregation in the following tests: platelet function, aggregation and in terms of the number of aggregation (adapalmetin, platelet count and mean platelet volume). Platelet function, platelet count and mean platelet volume were determined after 6 weeks of treatment and 6 hours of a 2 hour time interval between treatments. The results showed that the platelet function in the treated group (platelet count < 30/mm3) was significantly lower than that in the control group (platelet count 30.6, < 50/mm3). Platelet count in the treated group was significantly higher than that in the control group (platelet count 30.6 and<50) after 6 weeks of treatment. In the PlpI group, platelet aggregation was significantly lower than that in the control group (platelet count < 30/mm3) after 6 weeks of treatment. There was no significant difference between the two groups (platelet count 30.6 and <50/mm3). The present study shows that doxycycline (100mg/5ml) can reduce platelet function and reduce the number of platelet aggregation in patients with platelet injury. However, further studies should be conducted to determine the effect of doxycycline on platelet function.
Citation:Bhatia A, et al. (2023) Doxycycline-induced platelet damage in a rabbit model. PLoS ONE. 2024. e105996. https://doi.org/10.1371/journal.pone.00105996
Editor:M. Anmita T, N. T. H. Nguyen, University of Western Australia, Western Australia
Received:January 30, 2023;Accepted:April 6, 2024;Published:May 30, 2024
Copyright:© 2024leanor et al. This is an open-access article distributed under the terms of the, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Data Availability:All relevant data are within the paper and its Supporting Information files.
Funding:The author(s) received no specific funding for this work.
Competing interests:The authors have declared that no competing interests exist.
Platelets, a type of granules in the blood and tissues of the body, are a critical component of the circulatory system, and are the source of oxygen and nutrients for the body. Placental hormone and hormone-like growth factors, also referred to as HGH, are essential for the maintenance of a healthy circulatory system, and are present in the circulation of the various organs such as the heart, brain, liver and kidney. During the early stages of platelet development, platelets are released from their granules and then move through the vascular endothelium and enter the platelets. During the late stages of platelet development, platelets are released from their granules and then move through the blood vessels, and in the later stages, platelets are released from their granules and then move through the blood vessels and enter the platelets. In the present study, doxycycline (100mg/5ml) was administered to healthy volunteers to investigate the effect of doxycycline on platelet function and platelet aggregation.
The present study was undertaken to investigate the effect of doxycycline (100mg/5ml) on human platelets from healthy volunteers and from patients with and without previous platelet injury, to investigate the effect of doxycycline (100mg/5ml) on platelet function and the number of platelet aggregation and in terms of the number of platelet aggregation in the studied groups.
Give as directed by your veterinarian. Follow the instructions printed on the prescription label. Store doxycycline at room temperature. Be sure to complete the prescription to ensure a full recovery, even if your pet seems to be improving, unless instructed otherwise by your veterinarian. Allow your pet access to plenty of water. Doxycycline can be given with or without food but should not be given with dairy products.
Keep out of the reach of children and pets. Do not use in animals with a known sensitivity to doxycycline. Do not use in pregnant animals. Let your veterinarian know if your pet is on any other medications, as interactions with certain medicines can occur. Do not administer any calcium-containing medications, antacids, laxatives, or multivitamins within 2 hours of the last doxycycline dose. Notify your veterinarian if your animal suffers from kidney or liver disease. Doxycycline may increase skins sensitivity to sunlight. Store at room temperature. Store protected from light and moisture.
Allergic reactions and serious side effects are rare, but in the case of an allergic reaction or a serious side effect you should stop doxycycline treatment and seek veterinary attention. Some common signs of allergic reactions and serious side effects are hives, breathing difficulty, facial swelling, loss of appetite, or dark colored urine.
Should be stored at room temperature, away from moisture and heat.
Doxycycline should not be used in animals allergic to it or other tetracycline antibiotics. Use with caution in animals with impaired liver or kidney function. Do not use in pregnant, nursing, or growing animals since this medication may cause slowing of bone growth and discoloration of teeth. Give antacids, vitamin and mineral combinations, iron, or Pepto-Bismol at least 1 hour before or 4 hours after giving doxycycline. Use caution when given with digoxin or warfarin. Doxycycline is not affected by food.
Read the contraindications and add-backIf you are history taking a nitrofurantoine drug, discuss with your veterinarian how this medication could affect your treatment options. Do not give this medication to a healthy pregnant or nursing individual.
X
The above recommendations are provided by a combination of the most available scientific evidence and the information contained on the website. It is by far the largest and most comprehensive prescribing information available.
Stop use and seek professional help right away: rare side effects can sometimes be mild andچاھونوزیکالا. This medication may cause a mild nausea, vomiting, loss of appetite, weakness, diarrhea, stomach pain, loss of appetite, and/or weight loss.
Most side effects do not require any medical attention and are not dangerous.
The above recommendations are provided by a combination of the most available scientific evidence and information contained on the website.
N/A
Doxycycline Hyclateis a broad-spectrum antibiotic belonging to the tetracycline class, particularlyBroad-spectrum Antibiotic. It is used to treat a variety of bacterial infections including respiratory, skin, ear, and urinary tract infections. This medication should be used with caution in patients with a history of certain heart conditions, high blood pressure, or abnormal heartbeats. In addition to its primary uses as a treatment for respiratory infections, doxycycline may also be of some importance in the treatment of angioedema. In patients with certain heart conditions, doxycycline may be of particular importance as part of the topical form of the medication. Doxycycline is known for its ability to penetrate tissues and maintain their integrity, allowing the body to absorb and use its nutrients. It is often used in combination with other medications such as antibiotics to treat bacterial infections. It is important to note that doxycycline should only be used under the guidance and supervision of a healthcare professional, as this can cause serious side effects. Patients should be aware that certain precautions and warnings may be necessary while taking this medication. Before starting treatment with doxycycline, it is important to have a complete medical history, especially if you have a known allergy or skin condition. Doxycycline should not be taken by women or children due to the risk of birth defects or other reproductive problems. If you have any questions or concerns about the use of doxycycline, it is important to speak with a qualified healthcare professional. In conclusion, doxycycline is an effective medication for the treatment of bacterial infections, and it is important to use it as directed by a healthcare professional. Always follow the instructions provided by your healthcare provider or the specific medication label. If you have any questions or concerns about doxycycline, it is important to speak with a qualified healthcare professional.
Doxycycline Hyclate CapsuleDoxycycline Hyclate is a medication used to treat various bacterial infections. It is often prescribed to treat respiratory infections, skin infections, urinary tract infections, and certain sexually transmitted infections. It can also be used in combination with other medications to treat certain types of bacterial infections. However, it is important to note that doxycycline should only be used under the guidance and supervision of a healthcare professional, as this can cause serious side effects. It is essential to take doxycycline exactly as directed by a healthcare professional, and doxycycline may interact with other medications, especially with the use of antibiotics. It is also important to note that doxycycline may have potential side effects such as nausea, diarrhea, and headache. It is important to discuss any concerns or side effects with your healthcare provider before starting treatment with doxycycline.
Doxycycline CapsuleDoxycycline is a medication that is used to treat various bacterial infections. It is often prescribed to treat certain types of infections such as skin infections, respiratory tract infections, and sexually transmitted infections. Doxycycline is also sometimes used as part of a treatment plan to prevent the spread of sexually transmitted diseases such as chlamydia. However, it is important to discuss any concerns or side effects with your healthcare provider before starting treatment with doxycycline.
Doxycycline is an antibiotic medication that is commonly used to treat various bacterial infections. It works by killing or stopping the growth of bacteria. Doxycycline may also be useful in treating certain types of bacterial infections such as bronchitis, pneumonia, and sexually transmitted infections. Doxycycline is often prescribed to treat acne, rosacea, and certain types of acne. Doxycycline may also be of some importance in the treatment of certain types of bacterial infections. Doxycycline is often used in combination with other medications to treat certain types of bacterial infections. In addition to the aforementioned antibiotics, doxycycline is also sometimes used to prevent malaria in certain regions of the world. In addition to the aforementioned antibiotics, doxycycline is also sometimes used in combination with other medications to treat certain types of bacterial infections.
PHARMACIA
Harmacia is a broad-spectrum bacteriophage. It is used to treat a wide variety of infections caused by Streptococcus and S. aureus (penicillin, penicillin G), Staphylococcus aureus (ureobacter, Streptococcus pyogenes), E. coli (E.a.), and Haemophilus influenzae (H.
pneumoniae).Harmacia canin is used to prevent the spread of respiratory tract infections (e.g., pneumonia) caused by Streptococcus. S. aureus and Haemophilus influenzae can be treated with this medicine.
Harmacia canin is available as a capsule.
How to use this product:
Use this medicine with a full glass of water. Do not use the medicine if it is not the correct strength. Use only as prescribed by your doctor.
Precautions:
Keep this medicine out of reach of children. Do not use this medicine in the eyes. Do not give this medicine to other people even if they have the same symptoms as you. Avoid contact with eyes. It may cause you an allergy.
This medicine is a single dose and should not be used together with other medicines that can contain different ingredients. Do not use this medicine with other medicines that are not recommended. This medicine can cause a severe side effect. Consult your doctor for complete information.
Doxycycline 500mgEach capsule contains: Doxycycline 500mg
Tetracycline 20mgEach capsule contains: Tetracycline 20mg
Bacitracin TabletsEach capsule contains: Bacitracin Tablets
Penicillin G (Streptococcus pyogenes)Each capsule contains: Penicillin G (Streptococcus pyogenes)
Sulfa-TrimethoprimEach capsule contains: Sulfa-Trimethoprim
AcebuterolEach capsule contains: Terbinafine Hydrochloride 1%
VibramycinEach capsule contains: Vibramycin
Vibramycin Hydrochloride
Gentamicin HydrochlorideEach capsule contains: Gentamicin Hydrochloride 1%
Mesoridinium chlorideEach capsule contains: Mesoridinium chloride
ErythromycinEach capsule contains: Erythromycin
Aminoglycosides (antibiotics)
Penicillin-type antibiotics (antibiotics)Each capsule contains: Penicillin-type antibiotics (antibiotics) (prescription drug list). This medicine is used to treat bacterial infections (e.g., pneumonia, sinusitis).
Oxytetracycline-type antibiotics (antibiotics)Each capsule contains: Oxytetracycline Hydrochloride 1%
Nitrofurantoin TabletsEach capsule contains: Nitrofurantoin Tablets
Each capsule contains: Aminoglycoside antibiotics (prescription drug list).
Stade de France Pharmacy